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  • Dia 1
    Inhibition of endothelial cell proliferation 3 Inhibition of endothelial cell migration 4 4 Inhibition of matrix metalloproteinases 5 5 Inhibition of vessel maturation 6 Attenuation of tumor blood flow vascular

    Original URL path: http://www.angiogenesis.nl/vALA/lectures/Endothelial%20cells_bestanden/slide0019.htm (2015-08-10)
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  • (No additional info available in detailed archive for this subpage)
    Original URL path: /vALA/lectures/Endothelial%20cells_bestanden/fullscreen.htm (2015-08-10)


  • Dia 1
    Drugs that preferentially only affect cells of interest Facilitates targeted therapy Allows higher dosing Induces less side effects Requires cell specific target molecule non specific drug cell specific drug

    Original URL path: http://www.angiogenesis.nl/vALA/lectures/Drug%20discovery_bestanden/slide0015.htm (2015-08-10)
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  • Dia 1
    Drug discovery it takes two to tango

    Original URL path: http://www.angiogenesis.nl/vALA/lectures/Drug%20discovery_bestanden/slide0040.htm (2015-08-10)
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  • Dia 1
    molecules on endothelial cells VEGF Receptor EGF Receptor Molecules that cause activation Molecules that result from activation INT α V ß 3 CD44v3 CD105 FN EDB MMPs Galectins Tumor dependent

    Original URL path: http://www.angiogenesis.nl/vALA/lectures/Drug%20discovery_bestanden/slide0039.htm (2015-08-10)
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  • Dia 1
    Drug discovery flow chart

    Original URL path: http://www.angiogenesis.nl/vALA/lectures/Drug%20discovery_bestanden/slide0017.htm (2015-08-10)
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  • (No additional info available in detailed archive for this subpage)
    Original URL path: /vALA/lectures/Drug%20discovery_bestanden/fullscreen.htm (2015-08-10)