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  • Angiogenesis Laboratory Amsterdam VUMC - Angiogenesis workgroup - Researchline 1
    tumor tissues Van Beijnum et al Nature Protocols 2008 Our mission is to identify specific molecular changes on tumor endothelial cells that not only distuinguish them from normal resting endothelial cells but also from physiologically activated endothelial cells This enables the design and application of targeted therapies aimed at the tumor endothelial cell specifically without interfering with physiological angiogenesis From Van Beijnum et al Blood 2006 We also study the function and application of galectins in endothelial cell biology and tumor angiogenesis Galectins are a protein family that plays a role in different steps of tumor progression including angiogenesis immune escape and metastasis Thijssen Blood 2007 We have shown that multiple galectins are expressed by tumor endothelial cells Thijssen Am J Path 2008 In addition we found that inhibition of galectin 1 with the in house developed angiostatic peptide anginex is an effective anti cancer therapy Thijssen PNAS 2006 Thijssen Cancer Res 2010 Figure Tumor derived galectin 1 can compensate for the lack of galectin 1 in the tumor endothelium of gal 1 mice A overall tumor growth of two independent experiments with TC 1 lung carcinoma cells in gal 1 wt and gal 1 mice B immunohistochemical vessel staining

    Original URL path: http://www.angiogenesis.nl/Research_line1.htm (2015-08-10)
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  • Angiogenesis Laboratory Amsterdam VUMC - Angiogenesis workgroup - Researchline 2
    compensatory cytokines and growth factors like PlGF SDF 1 or erythropoietin in animals as well as cancer patients Ebos et al Proc Natl Acad Sci USA 2007 Vroling et al Angiogenesis 2009 This type of compensatory upregulation of signalling growth factors is at least partly explained by increased tumor hypoxia and consequent stabilisation of HIF 1a and increased transcription of gene programs under the control of HIF such as SDF 1 and VEGF Because there is still very little firm evidence from clinical studies giving insight into mechanisms of non responsiveness we study the mechanisms in vitro in tumor bearing mice and in clinical studies For a rational application of the current clinically most useful anti angiogenic multitargeted tyrosine kinase inhibitors TKIs like sunitinib or sorafenib it will be essential to understand the critical signalling pathways affected in the context of relevant micro environmental interactions between tumor and endothelial cells under hypoxic conditions Combined cellular pharmacological and phosphoproteomics and network analysis in tumor cells and ECs will provide new insights and understanding in mechanisms of response and resistance to TKIs Our ultimate aim is to improve the clinical use of these TKIs by either circumvention of resistance with alternative combination

    Original URL path: http://www.angiogenesis.nl/Research_line2.htm (2015-08-10)
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  • Angiogenesis Laboratory Amsterdam VUMC - Angiogenesis workgroup - Researchline 3
    Cancer 2005 Dings Cancer Res 2003 This beneficial effect is caused by a short period of vessel normalization which improves blood flow and oxygenation Dings et al Clin Cancer Res 2007 Little is known regarding the cellular mechanisms that underlie the response to combination therapy Furthermore it is important to determine the normalization window of angiostatic agents in order to optimize combination therapy Combination of radiotherapy and anti angiogenesis gives synergistic anti tumor effect Results give way to the hypothesis of vascular normalization From Dings et al Clin Cancer Res 2007 Angiogenesis and immunotherapy We investigate the relationship between angiogenesis and the immune system The ultimate goal is to investigate whether angiogenesis inhibition can be used to improve immunotherapy Endothelial cell adhesion molecules like intercellular adhesion molecule 1 ICAM 1 are suppressed by angiogenic growth factors such as bFGF and VEGF Griffioen et al Cancer Res 56 1111 1996 This leads to tumor escape from immunity Dirkx et al FASEB J 2006 Angiostatic factors can therefore improve immunotherapy Dings et al Clin Cancer Res 2011 Links below show video images of leukocyte vessel wall interactions in normal control tissue tumor tissue tumor tissue of mice treated with anginex Relationship between

    Original URL path: http://www.angiogenesis.nl/Research_line3.htm (2015-08-10)
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  • Angiogenesis Laboratory Amsterdam VUMC - Angiogenesis workgroup - Researchline 4
    Line I Line II Line III Line IV PhD theses Movies Funding Research line IV Personalized treatment strategies sorry this page is under construction

    Original URL path: http://www.angiogenesis.nl/Research_line4.htm (2015-08-10)
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  • Angiogenesis Laboratory Amsterdam VUMC - Angiogenesis workgroup - Theses
    W Griffioen Co promotor Dr P Soetekouw PhD theses Movies Publications ISBN 978 94 90371 59 3 Circulating endothelial and progenitor cells during anti angiogenic treatment in cancer patients Laura Vroling Promotor Prof Dr V W M van Hinsbergh Prof Dr H M W Verheul Co promotor Dr H J Broxterman ISBN 978 90 6464 210 4 Tumor cell plasticity vascularisation beyond angiogenesis Femke Hillen Promotor Prof Dr A W Griffioen ISBN 978 90 6464 206 7 Relationship between angiogenesis and immune response against solid tumors Karolien E R Castermans Promotor Prof Dr A W Griffioen ISBN 978 90 6464 154 1 Targeted treatment of cancer using the angiogenesis inhibitor anginex Ricardo J M G E Brandwijk Promotor Prof Dr A W Griffioen Co promotor Dr V L J L Thijssen ISBN10 90 6464 035 1 Epigenetic regulation of tumor angiogenesis Debby M E I Hellebrekers Promotor Prof Dr A W Griffioen Co promotor Dr M van Engeland ISBN10 90 3862 658 4 Lipid based nanoparticles for magnetic resonance molecular imaging Design characterization and application Willem J M Mulder Promotores Prof Dr K Nicolay Prof Dr A W Griffioen Small molecule vascular targeting agents evaluation of combinations with established anti cancer treatments and mechanisms of activity Bissan Ahmed Promotor Prof Dr P Lambin Co promotor Prof Dr A W Griffioen ISBN10 90 9020 568 3 Gene expression profiling of tumor angiogenesis Judy van Beijnum Promotor Prof Dr A W Griffioen ISBN10 90 8590 010 7 Interplay between tumor angiogenesis and the immune system Toward a new cancer Therapy Anita Dirkx Promotores Prof Dr J Wagstaff Prof Dr A W Griffioen Co promotor Dr M G A oude Egbrink ISBN 90 5278 506 6 Angiogenesis and leukocyte infiltration in malignant tumors Coen I M Baeten Promotor Prof Dr H F P

    Original URL path: http://www.angiogenesis.nl/Theses.htm (2015-08-10)
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  • Angiogenesis Laboratory Amsterdam VUMC - Movies
    it might take a few minutes to open a movie Nowak Sliwinska et al Cell Death Dis In press 2015 Hillen et al Biochem Biophys Res Comm 368 364 7 2008 Hellebrekers et al Cancer Res 2006 66 10770 7

    Original URL path: http://www.angiogenesis.nl/movies.htm (2015-08-10)
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  • welcome
    is therefore a target in the development of novel anti cancer therapies In th e virtual Angiogenesis L ab oratorium Amsterdam vALA you are in charge of developing new drugs for the treatment of cancer Based on a number of available assays and models you have to make the appropriate research decisions Beware hundreds of million s of people around the world are relying on your research skills in order

    Original URL path: http://www.angiogenesis.nl/vALA/index.htm (2015-08-10)
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  • Angiogenesis Laboratory Amsterdam VUMC - Angiogenesis workgroup
    started in 1998 at the University of Maastricht Local national and interantional experts give a seminar on an aspect of angiogenesis The goal of the Angiogenesis Workgroup is to create an international research discussion forum As of 2009 with the

    Original URL path: http://www.angiogenesis.nl/news_events_AWG.htm (2015-08-10)
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