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  • Brain-Train
    expectancy further enhances the impact of brain dysfunction on society In coming decades this burden will grow into one of most pressing and costly problems of the EU BrainTrain builded on our knowledge of genome information and exploits innovative technologies to unravel the dys function of living neurons networks and the whole brain BrainTrain delivered 17 skilled PhD students prepared for future challenges in neuroscience Summary of the project 3

    Original URL path: http://www.brain-train.nl/ (2016-04-29)
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  • Brain-Train
    the first Steering Committee meeting in Uppsala as fellows with all supervisors We discussed ECTS points time schedule for training and workshops in 2012 and other concerns of all fellows We will represent all early stage researchers again in the coming up annual meeting in September in Trieste Min SEOL Posted in weblog Leave a comment 2011 Tōhoku earthquake and tsunami By Davo Published April 5 2011 Having lived in Japan for almost a year I had already become accustomed to earthquakes Yokohama the city where I work has been relatively lucky in that earthquake epicenters have been quite far away Usually by the time the tremors reach my area only a small wobble can be felt However on Friday 11th of March as I was standing in the street I was sick that day and had just come out of the pharmacy I knew what I felt was different Read More Posted in weblog Leave a comment Behavioral experiments and data analysis By Torben Published January 12 2011 The first scientific BrainTrain course Behavioral experiments and data analysis will be held on the 19 21 January 2011 in the lab of Dr Oliver Stiedl in Amsterdam Read More Posted in weblog Leave a comment Photo s kick off meeting By christian bt Published November 4 2010 Hej Torben has written such a comprehensive summary that there is not much to add Maybe some pictures Read More Posted in weblog Leave a comment BrainTrain KickOff meeting 29 31 10 2010 Amsterdam By Torben Published November 1 2010 During the three days from Friday the 29th of Oct 2010 until Sunday the 31th of Oct 2010 all BrainTrain students the organising committee and a majority of the supervisors met in Amsterdam for the KickOff meeting of the BrainTrain project Read More

    Original URL path: http://www.brain-train.nl/training-2/weblogs/ (2016-04-29)
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  • Contact
    Amsterdam The Netherlands email e e n a r e s i s o tel 31 20 598 28 06 mobile 31 6 46 06 46 05 website www sylics com scientific coördinator Prof Matthijs Verhage Email m v e v Tel 31 20 59 86925 Events Training students can apply for the oncoming courses and workshops Read more Video JoVE video paper JoVE the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment We used the opportunity to create a video methods paper of the well established calcium imaging technique in immature brain slices Read more Research teams To reach its objectives the BrainTrain research program is composed of 5 scientific Research Teams see list below with 3 trainees each Genetics of the brain The increasing prevalence for neurodegenerative disease in our aging population poses a growing problem for healthcare Read more The synaptic interactome Many brain disorders are to be considered synaptic diseases or synaptopathies and cellular function of synapses Read more Functional genomic of the synapse The synapse is a specialized structure between two neurons at which basal neuronal communication takes

    Original URL path: http://www.brain-train.nl/contact/ (2016-04-29)
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  • BrainTrain consortium
    to unravel the dys function of living neurons networks and the whole brain Local specialists offered network wide training and meetings Our existing EU funded resources IP EUsynapse NeuroCypres and Neuromics EST will provide an excellent multicultural and inspiring environment for a new generation of integrative neuroscientists BrainTrain delivered 17 skilled ESR prepared for future challenges in neuroscience with optimal career opportunities and the ability to contribute to the fight against brain disorders BrainTrain consortium Goals and results Results Genetics of the brain Results Synaptic interactome Results Functional genomics Results Synaptic plasticity Results transmission behaviour Partners Partner information Students Vacancies Events Training students can apply for the oncoming courses and workshops Read more Video JoVE video paper JoVE the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment We used the opportunity to create a video methods paper of the well established calcium imaging technique in immature brain slices Read more Research teams To reach its objectives the BrainTrain research program is composed of 5 scientific Research Teams see list below with 3 trainees each Genetics of the brain The increasing prevalence for neurodegenerative

    Original URL path: http://www.brain-train.nl/braintrain-consortium/ (2016-04-29)
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  • Goals and results
    on brain research are the main objectives of the project The research objectives of BrainTrain Genetics of diseased brain dementia Parkinson s and major depressive disorder Results Neurodegenerative disease linked changes of the synaptic interactome Results Neurodegenerative disease linked molecular cellular variations in neurotransmission Results Impaired information processing in neuronal networks of diseased brain Results Therapeutics for diseased brain dementia Parkinson s and major depressive disorder Results BrainTrain consortium Goals and results Results Genetics of the brain Results Synaptic interactome Results Functional genomics Results Synaptic plasticity Results transmission behaviour Partners Partner information Students Vacancies Events Training students can apply for the oncoming courses and workshops Read more Video JoVE video paper JoVE the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment We used the opportunity to create a video methods paper of the well established calcium imaging technique in immature brain slices Read more brain consortium brain diseases brain disorders brain dysfunction brain research BrainTrain dementia depressive disorder diseased brain Early Stage Researcher ESR EUsynapse gene mapping genetic approach Genetics of the brain genomic genomic databases genomics Heidi de Wit human knowledge transfer

    Original URL path: http://www.brain-train.nl/braintrain-consortium/goals-and-results/ (2016-04-29)
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  • Results Genetics of the brain
    the reproducibility of the CAGE assay Since we have noted that noncoding RNAs are involved as early biomarkers and are involved as regulatory molecules in other various biological phenomena we have also further characterized a class of non coding RNAs essential for DNA repair published in Nature and further identified a large class of non coding RNAs deriving from retrotransposon elements We have also provided a broad map of expressed RNA in brain of aging patients and have made this resource public for other users Altogether we have deepened our knowledge of noncoding RNA expression in health and diseases focused on methods towards early diagnostic based on genomics exploration L Pardo P Rizzu M Francescatto M Vitezic G Leday J Sanchez A Khamis H Takahashi W van den Berg Y Medvedeva M van de Wiel C Daub P Carninci P Heutink Regional differences in gene expression and promoter usage in aged human brains Neurobiology of Aging 34 7 1825 1836 2013 Jul D Tang C Plessy M Salimullah A Suzuki R Calligaris S Gustincich P Carninci Suppression of barcode bias in high throughput transcriptome analyses utilizing template switching Nucleic Acids Research 41 1 12 2012 Nov S Francia F Michelini A Saxena D Tang MJ De Hoon A Viviana M Mione P Carninci F d Adda di Fagagna Site specific DICER and DROSHA RNA products control the DNA damage response Nature 488 231 235 2012 Aug Review Articles A Saxena D Tang P Carninci piRNAs warrant investigation in Rett Syndrome An Omics Perspective Disease Markers 33 261 275 2012 Sep B Lenhard A Sandelin P Carninci Metazoan promoters emerging characteristics and insights into transcriptional regulation Nature Reviews Genetics 13 233 245 2012 Apr BrainTrain consortium Goals and results Results Genetics of the brain Results Synaptic interactome Results Functional genomics Results

    Original URL path: http://www.brain-train.nl/braintrain-consortium/goals-and-results/results-genetics-of-the-brain/ (2016-04-29)
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  • Results Synaptic interactome
    final annual meeting at RIKEN Yokohama Publications Gorny X Mikhaylova M Seeger C Reddy P P Reissner C Schott B H Helena Danielson U Kreutz M R Seidenbecher C 2012 AKAP79 150 interacts with the neuronal calcium binding protein caldendrin J Neurochem 122 714 726 Hallermann S Fejtova A Schmidt H Weyhersmuller A Silver R A Gundelfinger E D Eilers J 2010 Bassoon speeds vesicle reloading at a central excitatory synapse Neuron 68 710 723 Seeger C Gorny X Reddy P P Seidenbecher C Danielson U H 2012 Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function J ournal of molecular recognition JMR 25 495 503 Valenzuela JC Heise C Franken G Singh J Schweitzer B Seidenbecher CI Frischknecht R Hyaluronan based extracellular matrix under conditions of homeostatic plasticity Philos Trans R Soc Lond B Biol Sci 2014 Oct 19 369 www ncbi nlm nih gov pubmed 25225099 Poster Abstracts AKAP79 150 and Caldenrin a New Relationship in the Synapse X Gorny M Mikhaylova B Schott M Kreutz C Seidenbecher 9th Göttingen Meeting Of The German Neuroscience Society March 23 27 2011 Abstr Nr T7 4a Role Of ADAMTS4 and Processing of Brevican in Synaptic Plasticity J C Valenzuela Macaya C Heise G Franken E D Gundelfinger C I Seidenbecher R Frischknecht 8th Fens Forum Of Neuroscience 2012 July 14 18 2012 Barcelona Spain Abstr Nr 2638 P 473 Decreased Brevican Levels are Associated with Increased Expression of Cocaine Induced Conditioned Place Preference B R Lubbers M C Van Den Oever R Frischknecht E D Gundelfinger C I Seidenbecher A B Smit S Spijker 8th Fens Forum Of Neuroscience 2012 July 14 18 2012 Barcelona Spain Abstr Nr 956 P 634 BrainTrain consortium Goals and results Results Genetics of the

    Original URL path: http://www.brain-train.nl/braintrain-consortium/goals-and-results/results-synaptic-interactome/ (2016-04-29)
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  • Results Functional genomics
    research outlined in WP3 has yielded new insight in cell to cell communication in neuronal networks on multiple levels ranging from intracellular mechanisms for neurotransmitter vesicle release in a single synapse to neuronal network activity in the intact brain of a live animal By this multi disciplinary research of genetic models for neurodegenerative disease this WP has delivered a deeper understanding of nerve cell connectivity which forms the basis of learning and memory Publications Kurps J and De Wit H The role of Munc18 1 and its orthologs in modulation of cortical F actin in chromaffin cells J Mol Neurosci 48 339 46 2012 Kurps J et al Novel image analysis tool to study the plasma membrane localization of secretory proteins and cortical actin in neurosecretory cells J Neurosci Methods submitted Walter A M Kurps J et al Vti1a functions in dense core vesicle biogenensis J Cell Biol submitted These authors contributed equally BrainTrain consortium Goals and results Results Genetics of the brain Results Synaptic interactome Results Functional genomics Results Synaptic plasticity Results transmission behaviour Partners Partner information Students Vacancies Events Training students can apply for the oncoming courses and workshops Read more Video JoVE video paper JoVE the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment We used the opportunity to create a video methods paper of the well established calcium imaging technique in immature brain slices Read more Research teams To reach its objectives the BrainTrain research program is composed of 5 scientific Research Teams see list below with 3 trainees each Genetics of the brain The increasing prevalence for neurodegenerative disease in our aging population poses a growing problem for healthcare Read more The synaptic interactome Many brain disorders are

    Original URL path: http://www.brain-train.nl/braintrain-consortium/goals-and-results/results-functional-genomics/ (2016-04-29)
    Open archived version from archive