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  • Synaptic interactome
    function of synapses At the basis of synaptic function is a collection of at most a thousand of different synaptic proteins the synaptic proteome that physically interact to form plastic signalling networks the synaptic interactome Synaptic function and the plastic changes thereof rely on the specific changes in physical interactions between the proteins of the synaptic interactome Likewise it is thought that synaptic diseases are caused by perturbations in the synaptic interactome that interfere with proper synaptic functioning Key objective In order to develop effective therapies for synaptic diseases it is imperative that the architecture and dynamics of the synaptic interactome are revealed and the disease causing changes in the interactome are identified The key objective of this Research Team is to provide a qualitative quantitative description of the extra synaptic interactome and to generate quantitative dynamical models of selected hubs such as the AMPA receptor AMPAR People Team 2 1 Student Nikhil Pandya Supervisor Prof Guus Smit Team 2 2 Student Juan Carlos Valenzuela Macaya Supervisor Prof Eckhardt Gundelfinger Team 2 3 Student Christian Seeger Supervisor Prof Helena Danielson Research teams Genetics of the brain Synaptic interactome Functional genomics Synaptic plasticity Video methods paper JoVE Nature Publication Transmission behaviour Events Training students can apply for the oncoming courses and workshops Read more Video JoVE video paper JoVE the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment We used the opportunity to create a video methods paper of the well established calcium imaging technique in immature brain slices Read more brain consortium brain diseases brain disorders brain dysfunction brain research BrainTrain dementia depressive disorder diseased brain Early Stage Researcher ESR EUsynapse gene mapping genetic approach Genetics of the brain genomic genomic databases genomics

    Original URL path: http://www.brain-train.nl/research-teams/synaptic-interactome/ (2016-04-29)
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  • Functional genomics
    transmission processes much remains to be delineated with respect to the molecular and cellular principles of synaptic delivery during neurotransmission and plasticity The involvement of synapses in a spectrum of major brain diseases synaptopathies such as neurodegenerative diseases dementia and Parkinson s and psychiatric disorders major depressive disorder is becoming increasingly apparent in recent years Key objective Therefore the key objective of this Research Team is to study which candidate genes regulate synaptic delivery and whether neurodegenerative disease linked variations in such genes isolated in Genetics of the Brain influence synaptic transport People Team 3 1 Student Julia Kurps Supervisor Dr Heidi de Wit Team 3 2 Student Laszlo Bicskei Supervisor Prof Angus Silver Team 3 3 Student Min Seol Supervisor Prof Thomas Kuner Research teams Genetics of the brain Synaptic interactome Functional genomics Synaptic plasticity Video methods paper JoVE Nature Publication Transmission behaviour Events Training students can apply for the oncoming courses and workshops Read more Video JoVE video paper JoVE the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment We used the opportunity to create a video methods paper of the

    Original URL path: http://www.brain-train.nl/research-teams/functional-genomics/ (2016-04-29)
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  • Synaptic plasticity
    X mental retardation protein FMRP respectively have been shown to strongly inhibit synaptic plasticity in hippocampal and cortical pathways The integrated approach of this team to target specific proteins in identified cells will elucidate their role in plasticity in context of neuronal networks and bridge the gap between genes and networks in information processing disorders Key objective The key objective of this Research Team is to investigate effects of specifically targeted molecules on synaptic plasticity within single neurons and their surrounding networks in models of cognitive impairment People Team 4 1 Students Ioannis Kramvis Julia Dawitz Supervisor Dr Rhiannon Meredith Team 4 2 Students Nicholas Rajan Giorgo La Fata Supervisor Prof Claudia Bagni Team 4 3 Student Silvia Lombardo Supervisor Dr Uwe Maskos Research teams Genetics of the brain Synaptic interactome Functional genomics Synaptic plasticity Video methods paper JoVE Nature Publication Transmission behaviour Events Training students can apply for the oncoming courses and workshops Read more Video JoVE video paper JoVE the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment We used the opportunity to create a video methods paper of the well

    Original URL path: http://www.brain-train.nl/research-teams/synaptic-plasticity/ (2016-04-29)
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  • Video-methods paper (JoVE)
    is some essential bit of the technique missing or a minor detail that has been overlooked in the protocol But what is it that you ve missed Given that you used a well written paper it is usually the little things that cannot be written down but can only be shown to you practically that are missing thus preventing the technique from working in your own lab JoVE the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment We used the opportunity to create a video methods paper of the well established calcium imaging technique in immature brain slices At the same time it allowed us to share a couple of experience based improvements to the method that we developed in the lab during the last two years We hope this movie gives those new to imaging techniques an insight into the detail of how these experiments are carried out Additionally we are sharing a couple of the in house developed improvements to the attention of fellow imaging researchers Research teams Genetics of the brain Synaptic interactome Functional genomics Synaptic plasticity Video methods paper JoVE Nature Publication Transmission behaviour Events Training students can apply for the oncoming courses and workshops Read more Video JoVE video paper JoVE the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment We used the opportunity to create a video methods paper of the well established calcium imaging technique in immature brain slices Read more Research teams To reach its objectives the BrainTrain research program is composed of 5 scientific Research Teams see list below with 3 trainees each Genetics of the brain

    Original URL path: http://www.brain-train.nl/research-teams/synaptic-plasticity/video-methods-paper-jove/ (2016-04-29)
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  • Nature Publication
    stages However it was not known whether such changes caused by lack of FMRP would occur prenatally at a stage when the layers of the cortex are forming The authors showed a delay in the transition of neurons to their correct layers in the developing cortex and that lack of FMRP affected levels of the protein N cadherin which regulates the maturation of neurons embryonically These deficits could be rescued if FMRP was re introduced back into the brain during prenatal stages Such timed delays in early brain formation were predicted to occur in Fragile X syndrome according to work by the Meredith group at the CNCR These latest findings now show such changes occurring in the brain at far earlier stages than previously documented in the mouse model or in people with Fragile X syndrome The research was led and coordinated by Professor Claudia Bagni and her team at VIB KU Leuven Belgium and Tor Vergata Italy The collaboration between the groups was supported by BrainTrain an EU Marie Curie training programme based at the CNCR www brain train nl Authors Giorgio La Fata VIB KU Leuven and Julia Dawitz INF department CNCR were affiliates of the programme working in host labs of Professor Claudia Bagni and Dr Rhiannon Meredith respectively FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry La Fata G Gärtner A Domínguez Iturza N Dresselaers T Dawitz J Poorthuis RB Averna M Himmelreich U Meredith RM Achsel T Dotti CG Bagni C http www nature com neuro journal v17 n12 full nn 3870 htm Research teams Genetics of the brain Synaptic interactome Functional genomics Synaptic plasticity Video methods paper JoVE Nature Publication Transmission behaviour Events Training students can apply for the oncoming courses and workshops Read more Video JoVE video paper JoVE

    Original URL path: http://www.brain-train.nl/research-teams/synaptic-plasticity/nature-publication/ (2016-04-29)
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  • Transmission / behaviour
    cognitive functions The involvement of synaptic proteins in a spectrum of major brain diseases synaptopathies including neurodegenerative diseases and affective disorders is increasingly evident Key objective Therefore the key objective of this Research Team is to study the consequence of interference with potential key molecules and adaptor proteins involved in regulation of synaptic function for cognitive function and autonomic regulation People Team 5 1 Student Torben Hager Supervisor Dr Oliver Stiedl Team 5 2 Students Tiberiu Stan Supervisor Dr Per Svenningsson Team 5 3 Student Suriya Navaneetha Manivannan Supervisor Dr Christian Gutzen Research teams Genetics of the brain Synaptic interactome Functional genomics Synaptic plasticity Video methods paper JoVE Nature Publication Transmission behaviour Events Training students can apply for the oncoming courses and workshops Read more Video JoVE video paper JoVE the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment We used the opportunity to create a video methods paper of the well established calcium imaging technique in immature brain slices Read more brain consortium brain diseases brain disorders brain dysfunction brain research BrainTrain dementia depressive disorder diseased brain Early Stage Researcher ESR EUsynapse

    Original URL path: http://www.brain-train.nl/research-teams/transmission-and-behavioural-function/ (2016-04-29)
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  • Training
    writing and scientific language writing English but also management courses computer skills project management team building Each individual trainee could make a selection from the workshops and courses offered by each of the BrainTrain network partners and require additional courses outside the given programme This resulted for each fellow in a BrainTrain certificate presented at the final conference in Japan Training Program agenda 2011 Program agenda 2012 Program agenda 2013 Course Schedule Program BrainTrain Conference Techniques Events Training students can apply for the oncoming courses and workshops Read more Video JoVE video paper JoVE the Journal of Visualized Experiments gives the opportunity to share a method with the science community by actually showing how to prepare and perform an experiment We used the opportunity to create a video methods paper of the well established calcium imaging technique in immature brain slices Read more Research teams To reach its objectives the BrainTrain research program is composed of 5 scientific Research Teams see list below with 3 trainees each Genetics of the brain The increasing prevalence for neurodegenerative disease in our aging population poses a growing problem for healthcare Read more The synaptic interactome Many brain disorders are to be considered synaptic

    Original URL path: http://www.brain-train.nl/training-2/ (2016-04-29)
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  • Program agenda 2011
    types of studies Examples of how these can be used for characterization of interactions will be presented When 7 9 December 2011 Where Uppsala 3 Annual Meeting When 10 December 2011 Where Uppsala 4 Neuropsychopharmacoly Lectures concerning the role signal transduction cascades in relation to emotional learning cognition and depression Experimental parts where the participants will by introduced to biochemical methods of studying intracellular signalling with an emphasis on whole animal experiments Behavioural methods to study emotional learning will also be presented and demonstrated When 12 15 December 2011 Where Stockholm Below you can find a brief overview of all the courses and workhops of BrainTrain Updates will be placed on the website regularly Courses BrainTrain courses workshops and conferences are open to students from outside the network Each workshop is introduced by a mini symposium on the topic by inter national speakers Lecturers in the courses are from the BrainTrain consortium and invited speakers Introduction course in Neuroscience and Omics Introduction in genetics proteomics and imaging as well as behaviour analyses related to brain diseases 3 days VUmc SYL Behavioral Neuroscience Data Analysis Introduction to the Viewer Software and its customization to different needs in various behavior essays e g spatial learning tasks such as the holeboard test and the Barnes maze test Synchronization with additional physiological measures such as ECG and neural activity 3 days Bonn Fragment based drug discovery From screening to design Introduction in fragment based drug discovery Overview of methods for design screening and optimization of fragment libraries fragment libraries for ligands against a certain target as well as computer based modelling of the interactions 7 days Beactica Molecular neuropharmacology techniques for behavioral phenotyping Introduction to protein phosphorylation in vivo assays to monitor cognitive and emotional processes in mouse models 7 days KI New optical and computational methods for investigating brain function ntroduction to new optical and computational methods neuroConstruct to study brain function at the synaptic neuronal and network level 3 days UCL Functional analysis of synaptoneurosomes and local protein synthesis Introduction to synaptoneurosomes preparation from different mouse brain areas Isolation of synaptically localized mRNAs Stimulation of synaptoneurosomes and study of local protein synthesis 4 days KU Leuven Integrative neurobiology of cholinergic systems Introduction to various effects of nicotine on behavior and electrophysiology by binding to different choline receptors providing new concepts with pharmacological relevance implications for patients with Parkinson s or Alzheimer disease 3 days IP Workshops BrainTrain courses workshops and conferences are open to students from outside the network Each workshop is introduced by a mini symposium on the topic by inter national speakers Lecturers in the courses are from the BrainTrain consortium and invited speakers Molecular imaging of neuronal cell surface molecules Introduction of single particle tracking SPT and fluorescence recovery after photobleaching FRAP focus on synaptonuclear signalling and extracellular brain matrix 3 days IfN Systems Neurobiology Introduction to transcriptome structure transcriptional network epigenomics and system biology of gene expression and nervous system function in combination with computational approach for drug

    Original URL path: http://www.brain-train.nl/training-2/program-agenda/ (2016-04-29)
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