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  • Neuroimaging and electroencephalographic changes after VNS - Epilepsie Vereniging Nederland
    more communicable with social smiles EEG before VNS showed frequents bursts of symmetric generalized polyspike waves 6 months after implantation EEG showed diffuse beta and gamma fast activities without epileptiform discharges DTI before VNS showed decreased fraction anisotropy in the right fimbria fornix 10 months after VNS showed improvement in this area PET before VNS showed extensive hypometabolism in the bilateral frontal parietal and temporal cortex after VNS this showed global improvement http www ncbi nlm nih gov pubmed 23643463 Comments reviewer prof Van Nieuwenhuizen first of all the clinical effects of VNS in this type of epilepsy syndrome is amazing With regards to the results of EEG DTI and PET a hypothesis is put forward containing that the anticonvulsive effects of VNS in MAE are related to improved glucose metabolism and white matter diffusion in the fornix which connects hippocampus and thalamus The thalamus may mediate cortical desynchronization accounting for anticonvulsive effect and cognitive improvement VNS publications overview Deze pagina delen Print deze pagina Professionals Voor iedereen die werkt met of voor mensen met epilepsie Forum Forum EpilepsiePlus Activiteiten Professionals Medische zorg Publicaties niet medicamenteuze behandelingen Nervus Vagus Stimulatie VNS Vagus nerve stimulation for drug resistant epilepsy Treatment of epilepsy by stimulation of the vagus nerve from Head and Neck surgical point of view Vagus nerve stimulation magnet activation for seizures The long term effect of VNS on QoL in patients with pharmacoresistant focal epilepsy Palliative epilepsy surgery in Aicardi syndrome Neuroimaging and electroencephalographic changes after VNS Additional publications April May 2014 Lead revision surgery for vagus nerve stimulation in epilepsy Outcomes of vagal nerve stimulation in a pediatric population Trigeminal nerve stimulation Additional publications February March 2014 Transcutaneus auricular vagus nerve stimulation Voice therapy in the treatment of dyspnea and dysphonia Additional publications January 2014 Effects of neuromodulation

    Original URL path: http://www.epilepsievereniging.nl/professionals/medische-sector/publicaties-niet-medicamenteuze-behandelingen/nervus-vagus-stimulatie/neuroimaging-electroencephalographic-changes-vns/ (2016-01-11)
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  • Additional publications April - May 2014 - Epilepsie Vereniging Nederland
    Prieto A Pardo J Osorio XR Arráez MA Neurosurg Rev 2014 May 18 Epub ahead of print PMID 24838990 PubMed as supplied by publisher Related citations Vagus Nerve Stimulation Howland RH Curr Behav Neurosci Rep 2014 Jun 1 2 64 73 PMID 24834378 PubMed Related citations Safe Use of Repetitive Transcranial Magnetic Stimulation in Patients With Implanted Vagus NerveStimulators Philip NS Carpenter SL Carpenter LL Brain Stimul 2014 Apr 12 pii S1935 861X 14 00129 6 doi 10 1016 j brs 2014 04 001 Epub ahead of print PMID 24794163 PubMed as supplied by publisher Related citations The long term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy The PuLsE Open Prospective Randomized Long term Effectiveness trial Ryvlin P Gilliam FG Nguyen DK Colicchio G Iudice A Tinuper P Zamponi N Aguglia U Wagner L Minotti L Stefan H Boon P Sadler M Benna P Raman P Perucca E Epilepsia 2014 Jun 55 6 893 900 doi 10 1111 epi 12611 Epub 2014 Apr 22 PMID 24754318 PubMed in process Related citations VNS publications overview Deze pagina delen Print deze pagina Professionals Voor iedereen die werkt met of voor mensen met epilepsie Forum Forum EpilepsiePlus Activiteiten Professionals Medische zorg Publicaties niet medicamenteuze behandelingen Nervus Vagus Stimulatie VNS Vagus nerve stimulation for drug resistant epilepsy Treatment of epilepsy by stimulation of the vagus nerve from Head and Neck surgical point of view Vagus nerve stimulation magnet activation for seizures The long term effect of VNS on QoL in patients with pharmacoresistant focal epilepsy Palliative epilepsy surgery in Aicardi syndrome Neuroimaging and electroencephalographic changes after VNS Additional publications April May 2014 Lead revision surgery for vagus nerve stimulation in epilepsy Outcomes of vagal nerve stimulation in a pediatric population Trigeminal nerve stimulation Additional publications February

    Original URL path: http://www.epilepsievereniging.nl/professionals/medische-sector/publicaties-niet-medicamenteuze-behandelingen/nervus-vagus-stimulatie/additional-publications-april-may-2014/ (2016-01-11)
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  • Lead revision surgery for vagus nerve stimulation in epilepsy - Epilepsie Vereniging Nederland
    and after VNS lead revision Results Seven patients had improvement in quality of life and three experienced no change Eight patients noted a restoration of clinical response comparable with initial VNS implantation Seven patients reported 30 60 improvement in seizure reduction two experienced 60 and one noted 30 Six patients had no change in AED burden No surgical complications occurred http www ncbi nlm nih gov pubmed 24389021 Comments rerviewer Prof van Nieuwenhuizen lead revisions are rare in VNS patients Lead replacement is recommended in lead discontinuity confirmed by cervical X rays or after a system diagnostic resulting in high or low impedance with a confirmed functional generator diagnostic indicating OK In this retrospective study 14 out of 263 patients needed lead revision 5 3 their common symptom being increased seizure frequency Lead revision is performed through the cervical incision used for initial implantation As dense adhesions and altered anatomy at the site of the electrodes are to be encountered and taking into account the low incidence of lead revision the technical skill of the surgeon is of great importance This study shows that after lead revision clinical response to VNS is restored quality of life remains the same or is improved and AED burden remains stable VNS publications overview Deze pagina delen Print deze pagina Professionals Voor iedereen die werkt met of voor mensen met epilepsie Forum Forum EpilepsiePlus Activiteiten Professionals Medische zorg Publicaties niet medicamenteuze behandelingen Nervus Vagus Stimulatie VNS Vagus nerve stimulation for drug resistant epilepsy Treatment of epilepsy by stimulation of the vagus nerve from Head and Neck surgical point of view Vagus nerve stimulation magnet activation for seizures The long term effect of VNS on QoL in patients with pharmacoresistant focal epilepsy Palliative epilepsy surgery in Aicardi syndrome Neuroimaging and electroencephalographic changes after VNS Additional

    Original URL path: http://www.epilepsievereniging.nl/professionals/medische-sector/publicaties-niet-medicamenteuze-behandelingen/nervus-vagus-stimulatie/lead-revision-surgery-vagus-nerve-stimulation-epilepsy/ (2016-01-11)
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  • Outcomes of vagal nerve stimulation in a pediatric population - Epilepsie Vereniging Nederland
    a 5 year period Patients with complete 6 and 12 month follow up data were included Analysis was also done across various subgroups including gender age at implantation seizure type abnormal MRI findings pre implantation number of medications at baseline history of SE and duration of epilepsy Results complete follow up data were available for 69 patients Median seizure reduction for these patients was 50 Q1 0 Q3 73 at 6 months and 40 Q1 25 Q3 75 at 12 months When stratified by baseline seizure frequency there was a significant reduction from baseline of 61 at 6 months and 69 at 12 months for patients in the high baseline frequency group There were no significant reductions at month 6 or 12 months for the lower baseline frequency group Adverse events were reported in 40 6 28 out of 69 patients Six patients had the VNS removed for reasons including lack of efficacy and side effects and were excluded from the study group http www ncbi nlm nih gov pubmed 24438620 Comments of reviewer Prof Van Nieuwenhuizen In this study a distinction is made between patients with high baseline frequency and with low baseline frequency cut off point is the median seizure frequency at baseline Cut off point was 45 seizures month 45 patients were low 34 patients were high At 6 months 53 6 of all patients had seizure reduction of 50 24 6 of 75 5 8 achieved seizure freedom 46 4 had a seizure reduction of 50 24 6 experienced an increased number of seizures compared to baseline The number of patients with increased seizures 17 of 69 is impressive Median reduction of seizures in the overall population was 50 High had a median reduction of 61 which was significantly lower than baseline Low experienced a 25 reduction At 12 months 40 6 of all patients had a seizure reduction of 50 24 6 75 5 8 were seizure free 59 4 had a seizure reduction of 50 28 9 experienced an increased number of seizures compared to baseline frequency Again number of patients with an exacerbation is considerable Median reduction of the overall population was 40 High had a significant median reduction of 69 whereas low did not show an overall reduction This study suggests greater potential of VNS in paediatric patients with higher frequencies The number of patients with increased seizure frequency 24 6 at 6 months 28 9 at 12 months is impressive VNS publications overview Deze pagina delen Print deze pagina Professionals Voor iedereen die werkt met of voor mensen met epilepsie Forum Forum EpilepsiePlus Activiteiten Professionals Medische zorg Publicaties niet medicamenteuze behandelingen Nervus Vagus Stimulatie VNS Vagus nerve stimulation for drug resistant epilepsy Treatment of epilepsy by stimulation of the vagus nerve from Head and Neck surgical point of view Vagus nerve stimulation magnet activation for seizures The long term effect of VNS on QoL in patients with pharmacoresistant focal epilepsy Palliative epilepsy surgery in Aicardi syndrome Neuroimaging and electroencephalographic changes after

    Original URL path: http://www.epilepsievereniging.nl/professionals/medische-sector/publicaties-niet-medicamenteuze-behandelingen/nervus-vagus-stimulatie/outcomes-vagal-nerve-stimulation-pediatric-population/ (2016-01-11)
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  • Trigeminal nerve stimulation - Epilepsie Vereniging Nederland
    period Results 8 patients completed the six month period a mean reduction in their daily seizure frequency of 47 9 was demonstrated In the other 10 patients who did not complete the six month period reasons to leave the study were interference of the external device with work 2 p difficulty in the constant use of the device 4 p fear of attracting the attention of others or ridicule 4 p and doubting the efficacy of the study 2 p Many patients did not tolerate intensity scales greater than 2 Adverse effects were sensation of pressure on the head pain skin reaction and tingling PMID 24761389 PubMed PMC3988608 Comments by reviewer Prof van Nieuwenhuizen this study is difficult to understand The exact distribution in 8 scales of intensity is not explained The number of patients who did not complete the six month period is considerable 8 out of 18 p However findings of this study are confirmed by a RCT carried out by De Giorgio et al Neurology 2012 80 9 786 91 They showed a responder rate seizure reduction 50 of 17 8 at 6 weeks and 40 5 at 18 weeks VNS publications overview Deze pagina delen Print deze pagina Professionals Voor iedereen die werkt met of voor mensen met epilepsie Forum Forum EpilepsiePlus Activiteiten Professionals Medische zorg Publicaties niet medicamenteuze behandelingen Nervus Vagus Stimulatie VNS Vagus nerve stimulation for drug resistant epilepsy Treatment of epilepsy by stimulation of the vagus nerve from Head and Neck surgical point of view Vagus nerve stimulation magnet activation for seizures The long term effect of VNS on QoL in patients with pharmacoresistant focal epilepsy Palliative epilepsy surgery in Aicardi syndrome Neuroimaging and electroencephalographic changes after VNS Additional publications April May 2014 Lead revision surgery for vagus nerve stimulation in epilepsy Outcomes

    Original URL path: http://www.epilepsievereniging.nl/professionals/medische-sector/publicaties-niet-medicamenteuze-behandelingen/nervus-vagus-stimulatie/trigeminal-nerve-stimulation/ (2016-01-11)
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  • Additional publications February - March 2014 - Epilepsie Vereniging Nederland
    K Cephalalgia 2014 Mar 7 Epub ahead of print PMID 24607501 PubMed as supplied by publisher Related citations Hyperinsulinemia potentiates airway responsiveness to parasympathetic nerve stimulation in obese rats Nie Z Jacoby DB Fryer AD Am J Respir Cell Mol Biol 2014 Mar 7 Epub ahead of print PMID 24605871 PubMed as supplied by publisher Related citations Soy isoflavone affects the autonomic nervous system in a tissue specific manner in anesthetized rats Tanida M Imanishi K Komatsu M Satomi J Yamamoto N Wang M Kurata Y Shibamoto T Exp Biol Med Maywood 2014 Feb 28 Epub ahead of print PMID 24586098 PubMed as supplied by publisher Related citations Loss of vagal tone aggravates systemic inflammation and cardiac impairment in endotoxemic rats Schulte A Lichtenstern C Henrich M Weigand MA Uhle F J Surg Res 2014 Jan 21 pii S0022 4804 14 00067 5 doi 10 1016 j jss 2014 01 022 Epub ahead of print PMID 24565505 PubMed as supplied by publisher Related citations Localization of α7 nicotinic acetylcholine receptor mRNA and protein within the cholinergic anti inflammatory pathway Downs AM Bond CE Hoover DB Neuroscience 2014 Feb 20 266C 178 185 doi 10 1016 j neuroscience 2014 02 011 Epub ahead of print PMID 24561218 PubMed as supplied by publisher Related citations The Role of Peripheral Reflexes in the Initiation of the Esophageal Phase of Swallowing Lang IM Medda BK Babaei A Shaker R Am J Physiol Gastrointest Liver Physiol 2014 Feb 20 Epub ahead of print PMID 24557762 PubMed as supplied by publisher Related citations Vagus Nerve Stimulation Delivered During Motor Rehabilitation Improves Recovery in a Rat Model of Stroke Khodaparast N Hays SA Sloan AM Fayyaz T Hulsey DR Rennaker RL 2nd Kilgard MP Neurorehabil Neural Repair 2014 Feb 18 Epub ahead of print PMID 24553102 PubMed as supplied by publisher Related citations Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia Oshinsky ML Murphy AL Hekierski H Jr Cooper M Simon BJ Pain 2014 Feb 14 pii S0304 3959 14 00070 0 doi 10 1016 j pain 2014 02 009 Epub ahead of print PMID 24530613 PubMed as supplied by publisher Related citations Vagal control of cardiac electrical activity and wall motion during ventricular fibrillation in large animals Naggar I Nakase K Lazar J Salciccioli L Selesnick I Stewart M Auton Neurosci 2014 Feb 2 pii S1566 0702 14 00011 3 doi 10 1016 j autneu 2014 01 009 Epub ahead of print PMID 24530112 PubMed as supplied by publisher Related citations Cardiac inotropic rebound effect after washout of acetylcholine is associated with electrophysiological heterogeneity in Langendorff perfused rabbit heart Luo H Si J Zhang F Yang Z Wang R Exp Ther Med 2014 Mar 7 3 755 757 Epub 2014 Jan 15 PMID 24520282 PubMed Free PMC Article Related citations Nav1 8 channels in ganglionated plexi modulate atrial fibrillation inducibility Qi B Wei Y Chen S Zhou G Li H Xu J Ding Y Lu X Zhao L Zhang F Chen G Zhao J Liu

    Original URL path: http://www.epilepsievereniging.nl/professionals/medische-sector/publicaties-niet-medicamenteuze-behandelingen/nervus-vagus-stimulatie/additional-publications-february-march-2014/ (2016-01-11)
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  • Transcutaneus auricular vagus nerve stimulation - Epilepsie Vereniging Nederland
    treatment eight patients 16 were seizure free 19 38 had reduced seizure frequency Conclusion Similar to the therapeutic effect of VNS ta VNS can suppress epileptic seizures and is a safe effective economical and widely applicable treatment option for drug resistant epilepsy http www ncbi nlm nih gov pubmed 24438620 Comments reviewer Prof Van Nieuwenhuizen this is an interesting study as non invasive stimulation of the vagal nerve may be an option to avoid some of the complications of VNS implantation infection However efficacy of ta VNS compared to implantation VNS might be significantly lower In this study 16 were seizure free and 38 had reduced seizure frequency In the McHugh study regarding implantation VNS Epilepsia 2007 Feb 48 2 375 8 16 5 had more than 80 seizure reduction 20 had a seizure reduction between 50 79 one third did not show any improvement whereas the remaining patients had a seizure reduction of less than 50 or had only magnet benefit Complication rate of ta VNS compared to implantation VNS is low three out of 47 patients 2 1 quit the study due to complications One patient complained of severe dizziness two patients reported red rashes and swelling Non implantation VNS remains an interesting option it might enable testing VNS sensibility before implantation is carried out VNS publications overview Deze pagina delen Print deze pagina Professionals Voor iedereen die werkt met of voor mensen met epilepsie Forum Forum EpilepsiePlus Activiteiten Professionals Medische zorg Publicaties niet medicamenteuze behandelingen Nervus Vagus Stimulatie VNS Vagus nerve stimulation for drug resistant epilepsy Treatment of epilepsy by stimulation of the vagus nerve from Head and Neck surgical point of view Vagus nerve stimulation magnet activation for seizures The long term effect of VNS on QoL in patients with pharmacoresistant focal epilepsy Palliative epilepsy surgery

    Original URL path: http://www.epilepsievereniging.nl/professionals/medische-sector/publicaties-niet-medicamenteuze-behandelingen/nervus-vagus-stimulatie/transcutaneus-auricular-vagus-nerve-stimulation/ (2016-01-11)
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  • Voice therapy in the treatment of dyspnea and dysphonia - Epilepsie Vereniging Nederland
    the glottic opening at rest became narrowed The right vocal fold which had normal range of motion with the VNS off exhibited hypomobility with decreased abductory range of motion when the VNS was on After deactivation complaints of dyspnea and dysphonia persisted Results Voice and respiratory retraining therapy was described initially for the ongoing period of VNS deactivation Therapy continued after reactivation of VNS therapy At long term follow up 13 months after completion of therapy and VNS reactivation the patient reported ongoing dyspneic symptoms which he was able to manage through the use of respiratory retraining therapy techniques Use of the same therapy techniques not only attenuated tonic symptoms of dyspnea but reportedly were preventative to the extent that the patient no longer experienced breathing attacks http www ncbi nlm nih gov pubmed 24070591 Comments reviewer Prof Van Nieuwenhuizen this case report is important because it focus attention on the possibility to relieve complaints of dysphonia and dyspnea in patients with VNS This might enable continuation of VNS in patients who have shown efficacy of VNS but who suffer from severe side effects VNS publications overview Deze pagina delen Print deze pagina Professionals Voor iedereen die werkt met of voor mensen met epilepsie Forum Forum EpilepsiePlus Activiteiten Professionals Medische zorg Publicaties niet medicamenteuze behandelingen Nervus Vagus Stimulatie VNS Vagus nerve stimulation for drug resistant epilepsy Treatment of epilepsy by stimulation of the vagus nerve from Head and Neck surgical point of view Vagus nerve stimulation magnet activation for seizures The long term effect of VNS on QoL in patients with pharmacoresistant focal epilepsy Palliative epilepsy surgery in Aicardi syndrome Neuroimaging and electroencephalographic changes after VNS Additional publications April May 2014 Lead revision surgery for vagus nerve stimulation in epilepsy Outcomes of vagal nerve stimulation in a pediatric population Trigeminal

    Original URL path: http://www.epilepsievereniging.nl/professionals/medische-sector/publicaties-niet-medicamenteuze-behandelingen/nervus-vagus-stimulatie/voice-therapy-treatment-dyspnea-dysphonia/ (2016-01-11)
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