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  • Erasmus MC : Instituten en faciliteiten
    Experimentele Medische Instrumentatie EMI Ontwikkeling van medisch wetenschappelijke apparatuur Optical Imaging Centre Snel naar Biomedische Wetenschappen intranet medewerkers Erasmus MC events calendar Medische Bibliotheek Vacatures promotieplaatsen Linker Menu Contact gegevens Afdelingen Instituten en faciliteiten Center for Biomics EDC ESRI Experimentele Medische Instrumentatie EMI iPS core faclity Optical Imaging Centre Proteomics Center Onderwijs Consortia en projecten Publiciteit Verwante bedrijven 010 704 0 704 Uw reactie Over deze site Disclaimer Privacy Cookies

    Original URL path: http://www.erasmusmc.nl/biomedicalsciences/Institutes-facilities/ (2015-12-02)
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  • Erasmus MC Biomedische Wetenschappen: Mission
    it is an essential prerequisite for regenerative medicine to flourish at the translational and clinical level Basic research in particular is one of the strengths of the Erasmus MC setting Bringing together the basic and clinical research expertise within Erasmus MC will greatly fuel the success of ESRI Core facilities Two important facilities within the ESRI are the induced Pluripotent Stem Cell iPS core facility and the Good Manufacturing Practice GMP unit together with the regulatory issues around development of Advanced Therapy Medicinal Products ATMP Medical Delta Success of stem cell research and regenerative medicine heavily relies on cross sectorial interaction of molecular biological clinical and technical expertise The Medical Delta offers great opportunities in this respect A major aim of the ESRI is to team up with LUMC and Technical University Delft to generate a Medical Delta nucleus for stem cell research and regenerative medicine Teaching program For the future development of stem cell and regenerative medicine research and successful implementation in clinical practice ESRI aims to establish presence in the regular medical curriculum and to develop specific trainings minors for medical and technical students Research focus ESRI will at first be based on three clinical focus areas neuro regeneration Neuro skeletal regeneration Skeleton and hematological regeneration Hematology All three areas will provide basic translational and clinical projects albeit to a varying degree The focus areas will encompass Research on individual genes proteins towards regulatory networks by systems biology types of project A combination of cell culture and ex vivo experimentation using e g sorted cells organoids and where essential experimental in vivo animal models It is the aim of ESRI to limit animal use and to develop and apply as much as possible alternative experimental models Early phase I II clinical studies with ATMP for regenerative purposes Zie

    Original URL path: http://www.erasmusmc.nl/biomedicalsciences/Institutes-facilities/esri/mission/ (2015-12-02)
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  • Erasmus MC : Core Facilities
    iPS facility Contact Mehrnaz Gahzvini Cell and Gene Therapy Contact Dr Eric Braakman ESRI Mission Research Core Facilities Links Contact ESRI home Linker Menu Contact gegevens Afdelingen Instituten en faciliteiten Center for Biomics EDC ESRI Experimentele Medische Instrumentatie EMI iPS core faclity Optical Imaging Centre Proteomics Center Onderwijs Consortia en projecten Publiciteit Verwante bedrijven 010 704 0 704 Uw reactie Over deze site Disclaimer Privacy Cookies 2015 Erasmus MC Deze

    Original URL path: http://www.erasmusmc.nl/biomedicalsciences/Institutes-facilities/esri/core_facilities/ (2015-12-02)
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  • Erasmus MC : Research
    Skeletal Bone Research program ESRI ESRI Mission Research Core Facilities Links Contact ESRI home Linker Menu Contact gegevens Afdelingen Instituten en faciliteiten Center for Biomics EDC ESRI Experimentele Medische Instrumentatie EMI iPS core faclity Optical Imaging Centre Proteomics Center Onderwijs Consortia en projecten Publiciteit Verwante bedrijven 010 704 0 704 Uw reactie Over deze site Disclaimer Privacy Cookies 2015 Erasmus MC Deze site maakt gebruik van cookies Lees meer Gezien

    Original URL path: http://www.erasmusmc.nl/biomedicalsciences/Institutes-facilities/esri/Research/ (2015-12-02)
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  • Erasmus MC Biomedische Wetenschappen: Introduction
    stem cells through development and differentiation Genetic and epigenetic programming of stem cells and their microenvironment Stem cell and related regenerative therapies These research lines are applied to several tissue systems identified as the strengths of the ESRI and Erasmus MC biomedical research communities and include blood intestine muscle bone and nervous systems and pluripotent cells Innovative technologies required to support these programs and in house translational expertise are available to expedite therapies A synergy between the scientists working on the individual tissue systems is already operating due to hypothesis driven stem cell related questions and through the common technologies exploited within the three integrated research lines Collaborations between investigators are abundant and are creating considerable added value Zie ook Nieuwsarchief Persberichten Mail de redactie Print Research topics ESRI Introduction Blood Intestinal and Lung Pluripotency Skeletal Bone Linker Menu Contact gegevens Afdelingen Instituten en faciliteiten Center for Biomics EDC ESRI Experimentele Medische Instrumentatie EMI iPS core faclity Optical Imaging Centre Proteomics Center Onderwijs Consortia en projecten Publiciteit Verwante bedrijven 010 704 0 704 Uw reactie Over deze site Disclaimer Privacy Cookies 2015 Erasmus MC Deze site maakt gebruik van cookies Lees meer Gezien Help mee onze website te verbeteren Please

    Original URL path: http://www.erasmusmc.nl/biomedicalsciences/Institutes-facilities/esri/Research/intro/ (2015-12-02)
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  • Erasmus MC Biomedische Wetenschappen: Blood
    a particularly interesting source since it is a highly vascularized tissue that is readily obtained and usually discarded at birth Dr Cupedo collaborates with Dr C Robin and Prof E Dzierzak in these developmental studies and leads a research program in human lymphoid tissue development Prof J Cornelissen and Dr T Cupedo are directing efforts towards novel methods of generating thymic epithelium to restore and direct lymphoid function in transplantation scenarios Molecular programming Molecular programming of HSCs in development and differentiation programs is a strong and internationally recognized area of research in the ESI The ability to manipulate the genetic and epigenetic program of HSCs or closely related cells greatly enhances our understanding of hematopoiesis but also provides new insights into possible molecular modulators for clinical use Analysis of the pivotal HSC transcription factors such as Runx1 Gata2 etc by Prof E Dzierzak has demonstrated a role for these factors in the generation of HSCs but not in their maintenance Maintenance of stem cell fate most likely rests in the epigenetic program and is intensively studied by the group of Prof F Grosveld Key biochemical and genetic technologies that allow the isolation of protein complexes have been developed in this laboratory Prof F Grosveld has identified some of the major players in transcriptional activation and or repression of the stem cell program Collaborative studies between these groups and that of Prof P Verrijzer Dept of Biochemistry are beginning to provide insights into how to manipulate stem cell fate and hold future promise for clinical exploitation Generation of human iPS cells from patients with blood related disease will allow further insight into the correction of such defects and strategies for clinical treatment Stem cell microenvironment interactions Further lines of research involve the isolation and characterization of the supportive hematopoietic microenvironment Prof E Dzierzak and Dr C Robin have identified several of the microenvironmental factors that lead to development of HSCs and produced a panel of stromal cells from the embryonic aorta region and the placenta both mouse and human that support hematopoiesis ex vivo from a variety of mouse and human cell types including ES cells The stromal cell lines are a valuable resource provided to the Erasmus MC and international research communities In collaboration with Dr R Stam and Dr M den Boer the stromal cells are being tested for their ability to expand leukemic cells in culture Studies of cancer stem cells in leukemia have been hindered previously due to the inability of the cells to grow ex vivo Cells of the bone marrow microenvironment in the osteoblastic and or vascular niches are thought to play a role in the normal maintenance of HSCs HSCs reside in close association with osteoblasts and the bone matrix Prof H van Leeuwen has developed and fully validated a human pre osteoblast based in vitro bone formation model and has profiled these cells at all stages of differentiation Studies in collaboration with Prof J Cornelissen are underway to study the impact of human

    Original URL path: http://www.erasmusmc.nl/biomedicalsciences/Institutes-facilities/esri/Research/blood/ (2015-12-02)
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  • Erasmus MC Biomedische Wetenschappen: Intestinal
    stem cells and tissue regeneration The most rapidly self renewing tissue in the body is the intestine Intestinal stem cells have been recently identified and characterized The Wnt signaling pathway is involved in normal physiologic self renewal of this tissue but is also involved in colon cancer Prof R Fodde is a leader in the field of cancer stem cells His group is involved in studies of the cell differentiation hierarchy and the mechanisms affecting the onset of colon cancer Label retention cell tracing methods are being used to study normal and neoplastic intestinal epithelium Zie ook Nieuwsarchief Persberichten Mail de redactie Print Research topics ESRI Introduction Blood Intestinal and Lung Pluripotency Skeletal Bone Linker Menu Contact gegevens Afdelingen Instituten en faciliteiten Center for Biomics EDC ESRI Experimentele Medische Instrumentatie EMI iPS core faclity Optical Imaging Centre Proteomics Center Onderwijs Consortia en projecten Publiciteit Verwante bedrijven 010 704 0 704 Uw reactie Over deze site Disclaimer Privacy Cookies 2015 Erasmus MC Deze site maakt gebruik van cookies Lees meer Gezien Help mee onze website te verbeteren Please help us improve our website Bedankt voor uw bezoek aan www erasmusmc nl U kunt helpen onze online dienstverlening te verbeteren door onze

    Original URL path: http://www.erasmusmc.nl/biomedicalsciences/Institutes-facilities/esri/Research/intestinal_lung/ (2015-12-02)
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  • Erasmus MC Biomedische Wetenschappen: Pluripotency
    how they make decisions to self renew or differentiation Dr Raymond Poot studies the protein interaction network in the differerentiation of ES cells towards the neuronal lineage Dr Joost Gribnau also uses ES cells to better understanding the process of X chromosome inactivation Along with ES cells he is interested in using iPS cells from patient material for these studies About three years ago a most remarkable discovery was made by the group of Yamanaka in which highly differentiated somatic cells were able to be reprogrammed to a pluripotent stage by forced expression of four factors known to be important in ES cell pluripotency The reprogrammed somatic cells became known as induced Pluripotental Stem iPS cells The ability to make patient disease carrying specific iPS cells holds great potential for translational research by providing in vitro lineage differentiation model systems for study of the onset of human disease To serve the research needs of the Erasmus MC research community Dr Gribnau has secured funds from the ESI Open call program to organize a core facility for the generation of patient specific iPS cells and to optimize the pluripotency of human ES cells and iPS cells as potent as mouse ES cells Specific optimization protocols are under study by Dr Derk ten Berge who is examining the impact of Wnts on the maintenance of ES cell pluripotency and the effects of Wnt on epiblast stem cells Zie ook Nieuwsarchief Persberichten Mail de redactie Print Research topics ESRI Introduction Blood Intestinal and Lung Pluripotency Skeletal Bone Linker Menu Contact gegevens Afdelingen Instituten en faciliteiten Center for Biomics EDC ESRI Experimentele Medische Instrumentatie EMI iPS core faclity Optical Imaging Centre Proteomics Center Onderwijs Consortia en projecten Publiciteit Verwante bedrijven 010 704 0 704 Uw reactie Over deze site Disclaimer Privacy Cookies 2015 Erasmus

    Original URL path: http://www.erasmusmc.nl/biomedicalsciences/Institutes-facilities/esri/Research/pluripotent/ (2015-12-02)
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