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  • Lifespannetwork - Publications 2009
    Partridge L Piper MD 2009 Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster PLoS ONE 2009 4 1 e4067 P14 Heijmans BT Tobi EW Lumey LH Slagboom PE 2009 The epigenome Archive of the prenatal environment Epigenetics 2009 Nov 6 4 8 Epub ahead of print P1 Hoeijmakers JHJ 2009 DNA Damage Aging and Cancer N Engl J Med 2009 361 1475 85 P19 Humphrey DM Toivonen JM Giannakou M Partridge L Brand MD 2009 Expression of human uncoupling protein 3 in Drosophila insulin producing cells increases insulin like peptide DILP levels and shortens lifespan Exp Gerontol 2009 May 44 5 316 27 P14 Ikeya T Broughton S Alic N Grandison R Partridge L 2009 The endosymbiont Wolbachia increases insulin IGF like signalling in Drosophila Proc Biol Sci 2009 Aug 19 Epub ahead of print P14 Iqbal A Piper M Faragher RG Naughton DP Partridge L Ostler EL 2009 Chemical changes in aging Drosophila melanogaster Age Dordr 2009 Jul 8 Epub ahead of print P14 Kappeler L De Magalhaes FC Leneuve P Xu J Brunel N Chatziantoniou C Le BY Holzenberger M 2009 Early postnatal nutrition determines somatotropic function in mice Endocrinology 2009 Jan 150 1 314 23 Epub 2008 Sep 18 P6 Kuningas M May L Tamm R van Bodegom D van den Biggelaar AH Meij JJ Frölich M Ziem JB Suchiman HE Metspalu A Slagboom PE Westendorp RG Selection for genetic variation inducing pro inflammatory responses under adverse environmental conditions in a Ghanaian population PLoS One 2009 Nov 11 4 11 e7795 Larbi A Pawelec G Witkowski J Schipper H Derhovanessian E Fulop T Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer s disease J Alzheimers Dis 2009 May 17 1 91 103 P8 POPULAR SUMMARY Larbi A Zelba H Goldeck D Pawelec G 2009 Induction of HIF 1α and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells J Leukoc Biol 2009 Nov 5 Epub ahead of print P8 POPULAR SUMMARY Larbi A Cabreiro F Zelba H Marthandan S Combet E Friguet B Petropoulos I Barnett Y Pawelec G 2009 Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation Free Radic Biol Med 2009 Sep 28 Epub ahead of print POPULAR SUMMARY May L van Bodegom D Kuningas M Meij JJ de Craen AJ Frölich M Westendorp RG Performance of the whole blood stimulation assay for assessing innate immune activation under field conditions Cytokine 2009 Mar 45 3 184 9 Epub 2009 Jan 29 May L van den Biggelaar AH van Bodegom D Meij HJ de Craen AJ Amankwa J Frölich M Kuningas M Westendorp RG Adverse environmental conditions influence age related innate immune responsiveness Immun Ageing 2009 May 30 6 7 Meij JJ van Bodegom D Ziem JB Amankwa J Polderman AM Kirkwood TB de Craen AJ Zwaan BJ Westendorp RG Quality quantity trade off of human offspring

    Original URL path: http://www.lifespannetwork.nl/index.cfm?p=BF686DE1-0BB4-0A09-D8BE50AE3AF5F427 (2016-04-28)
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  • Lifespannetwork - Publications 2010
    of print 2010 de Kloet ER From vasotocin to stress and cognition Eur J Pharmacol 2010 Jan 10 626 1 18 26 P2 LACDR Kuningas M van Bodegom D May L Meij JJ Slagboom PE Westendorp RG Common CFTR gene variants influence body composition and survival in rural Ghana Hum Genet 2010 Feb 127 2 201 6 Epub 2009 Nov 5 Larbi A Pawelec G Wong SC Goldeck D Tai JJ Fulop T Impact of age on T cell signaling A general defect or specific alterations Ageing Res Rev 2010 Oct 8 Epub ahead of print May L van Bodegom D Frölich M van Lieshout L Slagboom PE Westendorp RG Kuningas M Polymorphisms in TLR4 and TLR2 genes cytokine production and survival in rural Ghana Eur J Hum Genet 2010 Apr 18 4 490 5 Epub 2009 Oct 21 May L Kuningas M van Bodegom D Meij HJ Frolich M Slagboom PE Mantovani A Westendorp RG Genetic variation in pentraxin PTX 3 gene associates with PTX3 production and fertility in women Biol Reprod 2010 Feb 82 2 299 304 Epub 2009 Oct 21 Oberg S Cnattingius S et al Birth weight breast cancer revisited is the association confounded by familial factors Cancer Epidemiol Biomarkers Prev 2009 18 2447 52 Vicencio Oostra Maaike A de Jong Brandon M Invergo Fanja Kesbeke Franziska Wende Paul M Brakefield and Bas J Zwaan Translating environmental gradients into discontinuous reaction norms via hormone signalling in a polyphenic butterfly Proc R Soc B published online before print September 8 010 doi 10 1098 rspb 2010 1560 POPULAR SUMMARY photo Oskar Brattström photo Andre Coetzer photo Maaike de Jong Pawelec G Akbar A Beverley P Caruso C Derhovanessian E Fülöp T Griffiths P Grubeck Loebenstein B Hamprecht K Jahn G Kern F Koch SD Larbi A Maier

    Original URL path: http://www.lifespannetwork.nl/index.cfm?p=50999F68-3048-9110-62161100963641AE (2016-04-28)
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  • Lifespannetwork - Publications 2011 and later
    Fearnley A M James C M Porteous R A J Smith S Saeed J Carre M Singer D Gems L Partridge R C Hartley M P Murphy In vivo measurement of mitochondrial H2O2 using a ratiometric mass spectrometry probe shows an increase with aging that does not determine lifespan Cell Metab 2011 Mar 2 13 3 340 50 P Dalle Pezze A G Sonntag A Thien M T Prentzell M Gödel S Fischer E Neumann Haefelin T B Huber R Baumeister D P Shanley K Thedieck A Dynamic Network Model of mTOR Signaling Reveals TSC Independent mTORC2 Regulation SCIENCE Signalling 2012 27 March Vol 5 Issue 217 ra25 DOI 10 1126 scisignal 2002469 featured article mTOR focus issue Perspective from Fingar and Inoki Editorial Derhovanessian E Maier AB Hähnel K Beck R de Craen AJ Slagboom EP Westendorp RG Pawelec G Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late differentiated CD4 and CD8 T cells in humans J Gen Virol 2011 Aug 3 Epub ahead of print Karin E M Diderich Claudia Nicolaije Matthias Priemel Jan H Waarsing Judd S Day Renata M C Brandt Arndt F Schilling Sander M Botter Harrie Weinans Gijsbertus T J van der Horst Jan H J Hoeijmakers Johannes P T M van Leeuwen Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice Age DOI 10 1007 s11357 011 9291 8 2011 Aug 4 Published with open access at Springerlink com K Diderich M Alanazi J H J Hoeijmakers Premature aging and cancer in nucleotide excision repair disorders DNA Repair 10 2011 722 780 D Gems The problem of aging To treat or not to treat American Scientist 2011 99 278 280 D Gems Tragedy and delight The ethics of decelerated ageing Philos Trans R Soc Lond B Biol Sci 2011 Jan 12 366 1561 108 12 Van Ginhoven TM De Bruin RWF Timmermans M Mitchell JR Hoeijmakers JHJ IJzermans JNM Pre operative dietary restriction is feasible in live kidney donors Clin Transplant 2011 25 486 494 Herndler Brandstetter D Brunner S Weiskopf D van Rijn R Landgraf K Dejaco C Duftner C Schirmer M Kloss F Gassner R Lepperdinger G Grubeck Loebenstein B Post thymic regulation of CD5 levels in human memory T cells is inversely associated with the strength of responsiveness to interleukin 15 Hum Immunol 2011 Aug 72 8 627 31 Epub 2011 Apr 15 de Jong MA Wahlberg N van Eijk M Brakefield PM Zwaan BJ 2011 Mitochondrial DNA Signature for Range Wide Populations of Bicyclus anynana Suggests a Rapid Expansion from Recent Refugia PLoS ONE 6 6 e21385 doi 10 1371 journal pone 0021385 NEWS ITEM Dutch H Lans JM Lindvall K Thijssen AE Karambelas D Cupac Ø Fensgard G Jansen JHJ Hoeijmakers H Nilsen and W Vermeulen DNA damage leads to progressive replicative decline but extends the life span of long lived mutant animals Cell Death and Differentiation advance online publication 6 September 2013 doi 10 1038 cdd

    Original URL path: http://www.lifespannetwork.nl/index.cfm?p=BBA98928-C764-0026-A3129F8E8691F39E (2016-04-28)
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  • Lifespannetwork - Video - Deel 1 - Senex - Dutch
    levensduur kan verlengen besluit Rogier om hem meteen op te zoeken Het is het begin van een fascinerende reis in de wereld van verouderde cellen veroudering en levensduur Acteurs Bas Zwaan Rudi Westendorp David Gems Andres Metspalu Evelyna Derhovanessian Daryl Shanley Laurent Keller Ron de Kloet Riin Tamm John Jeffries Duur 24 minutes Indien u geïnteresseerd bent in een exemplaar van SENEX dan kunt u contact opnemen met het LifeSpan

    Original URL path: http://www.lifespannetwork.nl/index.cfm?p=637B09F7-C764-0026-A7D6804B17AC1487 (2016-04-28)
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  • Lifespannetwork - Teaching material - Dutch
    live forever over de biologie van veroudering waar 1 tot 14 lesuren aan besteed kan worden Er is ook een Engelstalige versie beschikbaar Een breed scala aan biologische onderwerpen uit verschillende domeinen en van verschillende organisatieniveaus komt aan bod De verschillende delen kunnen afzonderlijk of als geheel worden gebruikt Leerlingen bekijken onder meer filmpjes van wetenschappers over actueel biologisch onderzoek en kunnen het spel I want to make babies spelen De docentenhandleiding staat achter een wachtwoord op de website van De Praktijk bij Lesmateriaal downloaden U kunt zich gratis aanmelden op dezelfde pagina Doelgroep bovenbouw havo vwo Onderwerpen DNA stofwisseling cellen evolutie bloed afweer Lessen Videos met NLse ondertiteling volgen op korte termijn I want to live forever deel 1 Deel 1 film I want to live forever deel 2 havo Deel 2 havo filmpjes I want to live forever deel 2a Deel 2a filmpjes I want to live forever deel 2b Deel 2b filmpjes I want to live forever deel 2c Deel 2c filmpjes I want to live forever deel 2d Deel 2d filmpjes I want to live forever deel 2e Deel 2e filmpjes I want to live forever deel 3 Deel 3 filmpje I want to live forever

    Original URL path: http://www.lifespannetwork.nl/index.cfm?p=7BAEB727-C764-0026-AA2444C5F0091280 (2016-04-28)
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  • Lifespannetwork - Video - Part 2a - Daryl Shanley 3 – Gene regulation in C. elegans - Andres Metspalu 1 – Genetic variation in humans
    Partners Network Integration and collaboration Scientific Excellence Public communications Joint initiatives Please login Username Password Remember me on this computer Forgot your password Click here Videos Part 2a Daryl Shanley 3 Gene regulation in C elegans Andres Metspalu 1 Genetic

    Original URL path: http://www.lifespannetwork.nl/index.cfm?p=6276C6EC-C764-0026-ADC2333ECC32D5F0 (2016-04-28)
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  • Lifespannetwork - Video - Part 2b - Daryl Shanley 1 – Trade-off between longevity and reproduction
    Integration and collaboration Scientific Excellence Public communications Joint initiatives Please login Username Password Remember me on this computer Forgot your password Click here Videos Part 2b Daryl Shanley 1 Trade

    Original URL path: http://www.lifespannetwork.nl/index.cfm?p=6297D043-C764-0026-AF990DC4CA0F5E6E (2016-04-28)
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  • Lifespannetwork - Video - Part 2c - David Gems 2 – Ageing and diseases Evelyna Derhovanessian – The immune system and ageing Daryl Shanley 2 – From mother to grandmother
    Integration and collaboration Scientific Excellence Public communications Joint initiatives Please login Username Password Remember me on this computer Forgot your password Click here Videos Part 2c David Gems 2 Ageing and diseases Evelyna Derhovanessian The immune system and ageing Daryl

    Original URL path: http://www.lifespannetwork.nl/index.cfm?p=629947E2-C764-0026-AC5F6632D9250D18 (2016-04-28)
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