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  • News - UMC Utrecht
    suffering from multiple myeloma the most critical form of bone marrow cancer could benefit from being treated with a new drug called daratumumab The cancer cells in the bone marrow largely disappear in 40 percent of patients who receive this treatment The drug has a prolonged effect on this incurable disease The results of this study conducted by the University Medical Center UMC Utrecht in collaboration with Harvard University in the United States and several Danish and Swedish university hospitals are published in today s New England Journal of Medicine Dutch scientists develop method for identifying rare cells Monday 24 August 2015 Scientists of the Hubrecht Institute and the University Medical Center Utrecht developed a new method for identifying rare cell types by single cell mRNA sequencing The newly developed algorithm called RaceID is very useful for identifying rare cell types in normal and diseased tissue The research is published ahead of print on the website of Nature the 19th of August Drug resistant Hepatitis B Virus Still a Major Issue in Europe Wednesday 19 August 2015 The largest study ever conducted on drug resistance in patients infected with Hepatitis B Virus HBV in Europe shows that half of patients in whom HBV is not fully suppressed by treatment harbor the drug resistant virus This is because doctors in Europe are still prescribing old antiviral drugs which may also cause resistance to modern compounds The researchers reported these results in the latest issue of The Journal of Infectious Diseases published this week Top Dutch scientists join forces to combat antimicrobial resistance Tuesday 14 July 2015 Scientists at the University Medical Center UMC Utrecht Utrecht University and Wageningen UR have taken the initiative to concentrate expertise in the field of antimicrobial resistance To this end a virtual research center of Dutch

    Original URL path: http://www.umcutrecht.nl/en/Research/News (2015-12-02)
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  • Circulatory Health - UMC Utrecht
    are multifaceted an aging population and the rise in cardiovascular risk factors such as obesity and diabetes To face these challenges our teams within the UMC Utrecht Circulatory Health employ multidisciplinary integrated approach to advancing cardiovascular research and care Prof dr Rick Grobbee Diederick E Rick Grobbee is Professor of Clinical Epidemiology at the UMC Utrecht and member of the program committee of the Center for Circulatory Health and within this program he s chair of the steering committee care He is also Chief Scientific Officer at Julius Clinical Rick Grobbee has been a principal investigator in many large scale epidemiologic studies and randomized intervention trials relating to the prevention and treatment of cardiovascular disease His experience covers the full range of study designs including trials cohorts and case control studies In addition he has worked on theoretical principles and methods of diagnostic and prognostic research Full biography News Overview news Publications Publications October 2015 Publications September 2015 Publications August 2015 Publications July 2015 Publications June 2015 Publications May 2015 Publications April 2015 Publications March 2015 Publications January 2015 PhD Defenses PhD Defense F Nijhoff MSc Dec 03 Time 12 45 Location Utrecht University PhD Defenses November 2015 PhD Defenses December 2015 Follow us on Twitter CirculatHealth Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci https t co reY9QHtsQ8 Circulatory Health Reageer Retweet Good luck for M Weijmans who is now defending her phd thesis upon Family history of vascular disease the risk of cardiovascular events Circulatory Health Reageer Retweet societal relevance Julius Clinical Independent drug research The Circulatory Health program created significant societal impact with the spin off company Julius Clinical This academic research organization conducts national and international phase IIb IV clinical trials Since 2007 over 50 trials across more than

    Original URL path: http://www.umcutrecht.nl/en/Research/Research-programs/Circulatory-Health (2015-12-02)
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  • UMC Utrecht Center for Image Sciences - UMC Utrecht
    Division and comprises all research activities of the departments of Radiology Nuclear Medicine and Radiotherapy Core activities The UMC Utrecht Center for Image Sciences CIS is a worldwide leading center for translational medical imaging and image analysis for personalized image guided diagnosis and therapy The center focuses on medical imaging diagnosis tissue characteristics prognosis therapy prediction and monitoring image guided therapy and non invasive studies to image and monitor regenerative medicine applications Core competences of the center are image guided oncologic interventions MRI guided radiotherapy and brachytherapy MRI guided High Intensity Focused Ultrasound HIFU ablation and drug delivery radio embolization and pharmacotherapy Al activities in the center are directly related to the three main tasks of the University Medical Center Utrecht patient care innovative research education Medical equipment The center provides access to State of the art clinical imaging platforms including 13 MRI systems for diagnosis therapy planning and research ranging from 0 5 to 7 0T MRI guided high intensity focused ultrasound therapy HIFU for cancer treatment and local drug delivery MRI guided radiotherapy for cancer treatment using three integrated MR linear accelerator platforms as well as MRI guided brachytherapy Image guided treatment of metastasis in the liver bases

    Original URL path: http://www.umcutrecht.nl/en/Research/Research-programs/UMC-Utrecht-Center-for-Image-Sciences (2015-12-02)
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  • Jan Kimpen appointed Chief Medical Officer at Philips - UMC Utrecht
    on the HealthTech market Jan Kimpen will add a wealth of related experience to Philips senior management team and will report directly to Philips CEO Frans van Houten I am delighted that Jan Kimpen is joining us from UMC Utrecht which is a highly renowned and innovative hospital in the Netherlands said Frans van Houten The health care industry is undergoing a huge transformation Philips integrated approach to coordinated care across the health continuum is our answer to addressing the industry s dual challenge of delivering better patient care at lower costs Integrated solutions are at the core of our strategy and in his role as CMO Jan Kimpen will work closely with our global network of medical thought leaders to ensure that deep clinical insights and a people focused approach are at the heart of our propositions Jan Kimpen has worked for more than 18 years at the UMC Utrecht during his first ten years as Professor of Pediatrics at the Wilhelmina Children s Hospital In 2009 he was appointed President of the Board At the UMC Utrecht Kimpen strengthened ties with the Antoni van Leeuwenhoek Hospital Netherlands Cancer Institute and the Princess Máxima Center for Pediatric Oncology He

    Original URL path: http://www.umcutrecht.nl/en/Research/News/Jan-Kimpen-appointed-Chief-Medical-Officer-at-Phil (2015-12-02)
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  • UMC Utrecht discovers genetic cause of disturbed dental development - UMC Utrecht
    condition affects 14 out of every 10 000 people There are two types oligodontia as part of a syndrome and oligodontie as an isolated condition Genetic research We now know that 70 percent of oligodontia patients have mutations in several genes Further research was recently carried out at UMC Utrecht led by study leader Dr Gijs van Haaften The study involved additional genetic testing in 20 patients with nonsyndromic oligodontia using Whole Exome Sequencing WES WES is a technique for identifying the protein coding regions exome of the human genome The research results showed that in these patients the condition is often caused by a mutation in the LPR6 gene The study also revealed that patients have a 50 percent chance of passing on the mutation to their offspring Dr Marie José van den Boogaard clinical geneticist at UMC Utrecht explains In these patients the gene is primarily associated with the absence of teeth and in principle not with other serious conditions Bullied Oligodontia greatly impacts quality of life and may lead to eating and speaking problems among other things Dr Marijn Créton dentist and maxillofacial prosthetist at the Department of Oral and Maxillofacial Surgery and Special Dental Care at UMC Utrecht ensures in consultation with patients that ultimately they have a good set of teeth both at a young and adult age This requires a treatment of many years during which patients are treated by a dentist oral surgeon and orthodontist Moreover adolescents with oligodontia often have psychosocial issues says Créton Missing many teeth is conspicuous Children teenagers and young adults are sometimes bullied and regularly experience feelings of low self esteem and shame National Center of Excellence At the Center of Excellence in Congenital Orofacial and Dental Anomalies housed at UMC Utrecht dentists oral surgeons plastic surgeons and

    Original URL path: http://www.umcutrecht.nl/en/Research/News/UMC-Utrecht-discovers-genetic-cause-of-disturbed-d (2015-12-02)
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  • Dutch scientists develop method for identifying rare cells - UMC Utrecht
    the development and function of an organ it is essential to understand all characteristics of its cell types To distinguish between different cell types the gene expression levels of cells are measured With the emergence of advanced single cell mRNA sequencing thousands of gene expression levels in an individual cell can be measured This way a fingerprint of the cell can be made called a transcriptome which reveals the identity of a cell However the expression of a gene in a given cell type can be highly variable and the experimental procedure to sequence the transcriptome of a cell introduces additional variability This makes it very challenging to identify cell types in particular rare cell types that occur at very low frequency within an organ Identifying rare cell types is crucial to acquire a better understanding of normal or diseased tissue biology because they can carry out important functions in an organ Stem cells for example which give rise to all other cell types of an organ are typically rare and characterizing these cells could be the basis for regenerative medicine RaceID The scientists of the Hubrecht Institute led by director and professor of Quantitative Biology of Gene Regulation at

    Original URL path: http://www.umcutrecht.nl/en/Research/News/Dutch-scientists-develop-method-for-identifying-ra (2015-12-02)
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  • Research - UMC Utrecht
    loop where societal issues guide scientific research and where scientific results quickly move from bench to bedside Societal stakeholders are involved in all research phases from prioritizing research questions to evaluating impact Research programs Brain Center Rudolf Magnus Infection immunity Center for Circulatory Health Cancer Regenerative Medicine Stem Cells Child Health Research centers Julius Center Center for Molecular Medicine Center for Image Sciences Links Collaborations PhD MSc Careers Contact information

    Original URL path: http://www.umcutrecht.nl/en/Research.aspx (2015-12-02)
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  • wie we zijn - UMC Utrecht
    met patiënten en andere belanghebbenden vormen de basis voor excellente zorg Verbeteringen blijven in het UMC Utrecht niet op papier staan Ze worden daadwerkelijk toegepast in de praktijk Hoogwaardige opleidingen garanderen de instroom van nieuw talent dat nodig is om onze koppositie te behouden en versterken Missie Het UMC Utrecht is een internationaal toonaangevend universitair medisch centrum waarin kennis over gezondheid ziekte en zorg voor patiënt en samenleving wordt gemaakt getoetst gedeeld en toegepast IMPACT OP GEZONDHEID Het UMC Utrecht wil een belangrijke rol spelen in het internationale onderzoeksveld en toonaangevend zijn op het gebied van onderzoek en innovatie op een beperkt aantal terreinen de speerpuntprogramma s Want alleen zo kunnen we impact hebben op de gezondheid De kennis die we creëren willen we verder brengen richting klinische en haalbaarheidsstudies om vervolgens toe te passen in de kliniek We beperken onze rol dus niet tot het creëren van kennis we zetten ons juist actief in om de opgedane kennis en kunde geschikt te maken voor toepassing in de praktijk Zo komen we tot producten processen diensten voor de zorg en stimuleren we bovendien nieuwe bedrijvigheid Door het vermarkten van kennis en kunde kunnen ook patiënten in andere ziekenhuizen ervan profiteren SAMEN MET PATIËNTEN We zoeken verbinding met patiënten en andere belanghebbenden Bijvoorbeeld door hen te betrekken bij welk onderzoek we doen door hen te vragen bij te dragen aan het onderwijs deel te nemen aan onderzoek en mee te denken over hoe we de zorg moeten inrichten Daarnaast geven wij patiënten de regie over hun eigen behandeling gericht op hun persoonlijke behoeften Zo kunnen we een significante bijdrage leveren aan de gezondheid van mensen Hier en nu maar ook elders en in de toekomst BETROKKEN MEDEWERKERS Onze medewerkers zijn van doorslaggevende betekenis voor het UMC Utrecht We willen dan ook

    Original URL path: http://www.umcutrecht.nl/nl/Over-Ons/Wie-we-zijn (2015-12-02)
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